الفهرس | Only 14 pages are availabe for public view |
Abstract Background: In last years, accumulating evidence demonstrated that increased systemic inflammation is associated with poor cancer-specific survival in a variety of cancers (Proctor et al., 2010). These researches showed that the host’s inflammatory response to cancer and/or the systemic effects exerted by the cancer cells leads to upregulation of the inflammatory process, inducing the proliferation and metastasis of cancer cells by inhibiting apoptosis, promoting angiogenesis, and repairing DNA damage (McMillan et al., 2003).The existence of a systemic inflammatory response can be detected by both the elevation of the C-reactive protein (CRP) level and neutrophil-lymphocyte ratio (NLR). (Zahorec, 2001) |