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Abstract Slow coronary flow (SCF) phenomenon is a coronary microvascular disease diagnosed by detection of delayed dye opacification in coronary arteries during angiography in the lack of obstructive coronary artery disease. The incidence of SCF has been reported to be approximately 1-7% in patients who undergo a diagnostic coronary angiography due to suspected coronary artery disease. Patients who underwent coronary angiography between April 2015 and April 2016 at Agouza Police Hospital were evaluated for possible inclusion in the study. Out of the total population, 50 patients with SCF were included in the study group. The control group consisted of 50 age-matched subjects with normal coronary angiograms. The same exclusion criteria were applied to our study and the control groups. The distribution of cardiovascular risk factors, demographic characteristics, and laboratory parameters in the two groups are evaluated and we found that there were no differences between the patients with and without SCF with regard to gender, age and BMI (p>0.05). Among known CAD risk factors, diabetes mellitus and dyslipidemia were more prevalent in the CSF group than in the control group (24% vs. 6%, p = 0.023 and 50% vs. 24%, p = 0.041, respectively. while, History of smoking was more prevalent in CSF group however, this difference was not statistically significant. In the SCF group, TFCs measured in the left anterior descending artery, circumflex artery, and right coronary artery were significantly higher compared to the control group. In patients with CSF, the average frame count was 26.57 ±15.04, 28.67 ±6.3, and 25.52 ±7.67for corrected LAD, LCX, and RCA, respectively while in control patients, average frame count was 11.03 ±2.63, 13.13 ±3.36, and 11.34 ± 2.52 for corrected LAD, LCX, and RCA. The PDW (15.23 ± 2.31 vs. 13.86 ±1.89 p= 0.011), mean platelet volume (MPV) (11.34 ±1.26 vs. 10.61 ±0.95 p= 0.014), Platelet larger cell ratio (P-LCR) (32.03 ±8.51 vs. 28.14±7.14 p =0.012) were significantly increased in the CSF group relative to the control group. The other hematologic parameters such as Hb and RDW were similar in the two groups. Importantly, we found highly statistically significant difference between groups according to TFC, MPV, PDW and P-LCR. our study data showed that PDW >13.21, MPV > 9.88 and P-LCR >26.6 were predictors of the presence of CSF with sensitivities of 61% , 57% and 53% and specificities of 67% ,64% and 50%, respectively. |