الفهرس 
Mesenchymal stem cells (MSCs)Only 14 pages are availabe for public view
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Abstract
The aim of the present study was to evaluate the effect of intraarticular injection of BM-MSCs and CD-MSCs in treatment of acute cartilage injury of the rabbit’s knee as a prophylactic measure from osteoarthritis. Twenty-five adult female baladi rabbits were used. 5 rabbits were used for preparation of bone marrow mesenchymal stem cells (BM-MSCs) and their left knees were not subjected for surgical procedure and used as normal control group. Twenty animals were subjected to surgically induced cartilage defect. The surgical procedure was done under general anesthesia through a small medial parapatellar incision in the left knee. The lower end of the femur is exposed and articular cartilage injury was created using a bone curette. In the next day of the surgical procedure, the twenty rabbits were classified into 4 groups (5 Rabbits each) and treated as follows: group I: the rabbits were left without treatment (Sham operated). group II: the left knee of each rabbit was subjected for intra-articular injection by a single dose of 0.5 ml saline (sham operated). group III: the left knee of each rabbit was subjected for intra-articular injection by a single dose of bone marrow derived mesenchymal stem cells (BM-MSCs). group IV: the left knee of each rabbit was subjected for intra-articular injection by a single dose of chondrogenically differentiated mesenchymal stem cells (CD-MSCs)