الفهرس 
Acute Myeloid LeukeimaOnly 14 pages are availabe for public view
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Abstract
please write abstract.Acute myeloid leukemia (AML) is a clonal hematopoientic stem cell disorder, characterized by infiltration of the bone marrow, blood, and other tissues by proliferative, clonal, abnormally differentiated, and occasionally poorly differentiated cells of hematopoietic system. AML is a highly heterogeneous disease, with biologically and prognostically different subtypes distinguished by cytogenetic and molecular genetics analyses. DNA methyltransferase 3A (DNMT3A) is one of two human de novo DNA methyltransferases essential regulating gene expression during cellular development and differentiation. DNMT3A mutations and deletions have been previously observed in acute myeloid leukemia (AML), PCR and direct sequencing was performed to analyze mutations of DNMT3A amino acid residue 882.