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Abstract CO is a toxic gas resulting from incomplete combustion of organic matter. The main manifestations of acute CO poisoning develop in the systems most dependent on oxygen, CNS and heart. Several factors have been suspected to be predictors for intoxication severity and development of DNS. This study included 20 control and 76 patients diagnosed as acute CO poisoning. Physical, neurological examinations and laboratory investigations were carried out to all of them. This study revealed that plasma copeptin level can be predictor of COHb level and thus can predict severity of acute CO poisoning, while predictors for DNS were respiratory rate, GCS, syncope, CK-MB, plasma copeptin and COHb levels. The cutoff value of plasma copeptin level of < 400 pg/ml predicted mild poisoning, 400-490 pg/ml moderate, > 490pg/ml severe, while > 500 pg/ml predicted DNS. |