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Abstract Cardiovascular pathology remains the leading cause of morbidity and mortality in patients with chronic kidney disease and the prevalence of vascular calcification among dialysis patients is very high. Fetuin-A is a liver-derived potent systemic inhibitor of calcification and a negative acute phase reactant. The aim of the present study is to investigate the associations of serum fetuin-A level with coronary calcification score, a marker of vascular calcificatin and common carotid IMT as a marker of early atherosclerosis. Sixty two patients were included in the study . All patients were from the Dialysis Unit of Minia university hospital We include clinically stable patients on chronic maintenance HD for at least three months and exclude patients receiving antibiotics or immunosuppressive agents, Patient with acute inflammation and patient with liver cirrhosis. All patients was subjected to Full history taking, Thorough clinical examination, Serum albumin ,creatinine , urea, blood hemoglobin, Serum Calcium , Phosphorus, vitamin D intact parathyroid hormone, Serum levels of fetuin-A, Abdominal ultrasonography, Coronary calcification score by chest computed tomography, Carotid intimal medial thickness measurement by carotid duplex. The results showed that there was no association between serum fetuin-A and both coronary artery calcification score (CAC) or carotid intimal medial thickness (IMT). |