الفهرس | Only 14 pages are availabe for public view |
Abstract Anti-inflammatory drugs are the most widely administered drugs world-wide for alleviating inflammation or reducing the effect of the substances that released at the site of inflammation in both human and veterinary practice. Anti-inflammatory drugs include both non-steroidal anti-inflammatory drugs (NSAIDs) and steroidal anti-inflammatory drugs (Glucocorticoids). The current study was outlined to look into the effect of ketoprofen (as a non-steroidal anti-inflammatory drug) and prednisolone (as a steroidal anti-inflammatory drug) on some serum biochemical parameters (kidney function tests, liver function parameters, minerals and electrolyte levels, parathyroid hormone level and lipid profile), with special reference to their histopathological effects on some vital organs (e.g. liver, kidneys and heart). Forty-five adult male albino rats weighing 150-200 gm were allocated into three groups, 15 rats each as follows: The 1st group: (Control) Rats in this group were left as control. The 2nd group: (Ketoprofen treated group). Rats in this group received ketoprofen at a dose of 5 mg/kg b.wt. subcutaneously (S/C) once a day for 14 days. The 3rd group: (Prednisolone treated group). Rats in this group received methylprednisolone at a dose of 10 mg/kg b.wt. intramuscularly (I.M.) once a week for 2 weeks. |