الفهرس 
Diabetes MellitusOnly 14 pages are availabe for public view
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Abstract
Background: Diabetes mellitus (DM) is a multifactorial disease associated with hyperglycemia and increased risk of micro and macrovascular complications which are the major causes of morbidity and mortality. The primary causal factor leading to the pathophysiologic alterations in the diabetic vasculature is chronic exposure to high blood glucose level. Under hyperglycemic conditions, glucose and other reducing sugars react nonenzymatically with proteins and lipids leading to formation of advanced glycation end products (AGEs) at an accelerated rate.There is growing evidence that production and accumulation of AGEs is involved in the initiation and development of micro and macrovascular complications observed in diabetes mellitus.The effects of AGEs have been shown to be partially mediated via cellular receptors called the receptor for AGEs (RAGE). At least 30 polymorphisms have been identified within RAGE gene, the most important two polymorphisms in the promotor region that have been highlighted in many studies are 374T/A and 429T/C SNPs. Many studies on different population have investigated the association of 374T/A and 429 T/C polymorphisms with diabetic vascular complication as they affect transcription activity of RAGE but the results were conflicting. Objectives: was to investigate the association of 374T/A and 429T/C RAGE gene polymorphisms with diabetic vascular complications. Methods: This study conducted on thirty sex (36) adult patients with type 2 diabetes mellitus divided into 18 patients with microvascular and 18 patients with macrovascular complications. The control group included fifteen (15) age- and sex-matched diabetic patients without vascular complications. Assay of RAGE gene polymorphism was by PCR-RFLP analysis. Results: the genotype analysis showed that there is no significant difference between patients and controls as regard all genotypes of the two single nucleotide polymorphisms (SNP) 374 T/A and 429 T/C (P value = >0.05). Conclusion: the study had demonstrated that there is no significant association between RAGE gene polymorphisms 374T/A and 429 T/C and diabetic vascular complications in Egyptian population