الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 149 |  |  |
| | | from | 149 | | |
Abstract
The correlation between lead toxicity and infertility was confirmed by many studies. The present study aimed to explore the effect of L-carnitine on the adverse effects caused by lead metal on female rat fertility. Animals were organized into four groups (negative control group, lead acetate positive control group (50mg/l), L-carnitine low dose group (50mg/Kg BW/day) and L-carnitine high dose group (100mg/Kg BW/day). After 21 days, the period of treatment blood samples were collected for estradiol concentration measurement and female rat ovaries were excised for lead residue, MDA, activities of SOD and GPx measurement, and CYP19A1 gene expression assessment in one ovary. The second ovary used in Histopathological examination. All samples were collected according to the four phases of the estrous cycle. The results of the present study revealed that lead metal causes significant increase (p<0.05) in the oxidative stress parameter (MDA) while it causes significantly decreases (p<0.05) in the activities of antioxidant enzymes (SOD and GPx), the relative expression of CYP19A1 gene expression and estradiol hormone level. L-carnitine have an outstanding beneficial effects on the previous parameters which increased by increasing the dose. Therefore, the potential of using L–carnitine to combat lead metal adverse effects on female infertility is very promising.