الفهرس | Only 14 pages are availabe for public view |
Abstract Fifty adult albino rats were used in this study; the rats were divided equally into five groups: group I (negative control group): rats were injected subcutaneously by 1 ml distilled water for 2 consecutive days, group IIa (ISO group): rats were scarified after two days from the induction of infarction, group IIb (Captopril group): rats were given Captopril (two g/liter drinking water) starting two days after induction of infarction and lasting for four weeks, group IIc (Rosuvastatin group): Ten rats were given rosuvastatins (10 mg/kg) by gastric gavage for four weeks and group IId (Captopril and Rosuvastatin group): rats were given both Captopril (2 g/liter drinking water) and rosuvastatins (10 mg/kg) simultaneously for four weeks.Microscopic examination of H&E and Masson trichrome stained sections revealed newly formed blood vessels and decreased in the percentage area of fibrosis in the MI rats treated with rosuvastatin as well as captopril and rosuvastatin but not in MI rats received no treatment or treated by captopril. The immune histochemical studies showed newly formed blood vessels in the infracted myocardium.Based on the results presented; The treatment with rosuvastatin can restore the histological architecture of the heart and minimized the fibrotic area following experimental myocardial injury by ISO administration. This beneficial effect was mostly related to its angiogenic properties. |