الفهرس 
Left ventricular dysfunctionOnly 14 pages are availabe for public view
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Abstract
Background and Aim: Left ventricular dysfunction has become an overwhelming condition that results in deleterious complications like arrhythmia and sudden cardiac death. The present study was conducted to evaluate the possible beneficial effects of co-administration of aliskiren to perindopril or telmisartan on cardiac functions, oxidative stress, and fibrosis and histopathological changes in an animal model of left ventricular dysfunction induced by doxorubicin in (L-NAME) hypertensive rats.
Method: 48 male albino rats (6 per group) were randomly assigned to the normal naïve control, L-NAME /Doxorubicin, L-NAME /Doxorubicin + DMSO, aliskiren, perindopril, telmisartan, aliskiren + perindopril, aliskiren + telmisartan (all drugs were taken in the last 3 weeks by gastric gavage).
Parameters measured: Haemodynamic parameters; (rat tail systolic blood pressure (SBP), left ventricular end diastolic pressure (LVEDP), left ventricular dP/dtmax. Biochemical parameters; (cardiac malondialdehyde (MDA), cardiac superoxide dismutase (SOD), cardiac transforming growth factor beta (TGF-β), urinary level of albumin, creatinine clearance. Histopathological changes in the cardiac tissue; stained with Hematoxyline and Eosin (H&E) and Masson Trichrome stain.
Results: All treated groups produced significant decrease in SBP compared to their corresponding 5th week. Significantly they decreased LVEDP, MDA, TGF-β, urine albumin and increased LV dp/dtmax, SOD and creatinine clearance . Additionally, cardiac histopathological sections of treated rats showed decreased in inflammatory cells and collagen fiber deposition and significant reduction in percentage area of collagen compared to L-NAME/DOX untreated rats.
Aliskiren combination with either perindopril or telmisartan produced significant decrease in SBP, LVEDP, TGF-β, urinary albumin (as compared to telmisartan only) and significant increase in SOD, creatinine clearance compared to either drug alone. In addition, the combination produced apparent improvement in cardiac histopathology with significant decrease in fibrosis and significant reduction in percentage area of collagen compared to either drug alone.
Conclusion: It is concluded that Co-administration of aliskiren to perindopril or telmisartan in a rat model of left ventricular dysfunction induced by doxorubicin in L-NAME hypertensive rats produced more improvement of the left ventricular function and renal function than using either drug alone.
This effect was evidenced and explained by, the additive cardio and reno-protective effect of aliskiren in reducing oxidative stress and fibrosis of the cardiac tissues.