الفهرس 
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Abstract
Phytochemical, toxicological and pharmacological studies were carried out on Calendula officinalis flower commonly used in folk medicine. Flowers different phytochemicals were analyzed. The Calendula officinalis flower 70 % ethanolic extract toxicological studies (Acute and chronic toxicity) were investigated. The oral anti-inflammatory, antipyretic, analgesic, anticonvulsant, tranquilizing and hypnotic activities of Calendula officinalis flower 70% ethanolic extract were studied. Hepatoprotective, diuretic, healing, hormone like activity and effect of tested extract on male fertility were also investigated. Moreover Calendula officinalis 70% ethanolic extract genotoxic, in vitro antibacterial and antispasmodic activities (on isolated rabbit’s duodenum) were analyzed. Phytochemical analysis of Calendula officinalis flower revealed the presence of flavonoids, glycosides, tannin, saponins, resin and absence of alkaloids. Calendula officinalis LD50 was 2450 mg/Kg b.wt. Prolonged administration of Calendula officinalis 70% ethanolic extract (12 weeks) produced significant increase in number of leucocytes, decrease in ALT and AST enzymes. Studied extract showed significant anti-inflammatory, antipyretic, analgesic, anticonvulsant, tranquilizing, hepatoprotective, diuretic, estrogen, progesterone, healing, antigenotoxic, antispasmodic and antibacterial activities.