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العنوان
Serum level of Interleukin -17 in the patients with cutaneous warts /
المؤلف
Megella, Mira Khalil Found.
هيئة الاعداد
باحث / ميرا خليل فؤاد مجلع
مشرف / حنان عبدالراضي متولي
hanan_asaf@med.sohag.edu.eg
مشرف / محمد أبوالحمد علي
مناقش / عصام الدين عبد العزيز ندا
essameldin_nada@med.sohag.edu.eg
مناقش / حاتم زيدان محمد
الموضوع
Skin Diseases, Infectious therapy. skin Cancer. Papillomaviruses. Papillomavirus diseases. Interleukins Therapeutic use Testing.
تاريخ النشر
2016.
عدد الصفحات
99 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الأمراض الجلدية
تاريخ الإجازة
2/7/2016
مكان الإجازة
جامعة سوهاج - كلية الطب - الأمراض الجلدية
الفهرس
Only 14 pages are availabe for public view

from 120

from 120

Abstract

Cutaneous warts are widespread in the worldwide population. Cutaneous warts are the most common cutaneous infection occurring when immune function is impaired. High immunity leading to wart regression is essentially universal, but poorly understood.
Hereby, it is worth mentioning that, to the best of our knowledge, the serum levels of IL17 cytokine profile were not studied in cutaneous warts before. This present study aimed to investigate the serum levels of IL 17 in the patients with different cutaneous warts by ELISA compared with healthy control participants.
The present study found that there was a statistically significant difference between serum levels of IL17 in the patients with different cutaneous warts and healthy control participants. Serum levels of IL17 were significantly decreased in the patients with cutaneous warts. So, this low serum level of IL17 could be an important immunological factor for increasing the risk of HPV infections and development in different cutaneous warts.
This study found that there was no statstically significant correlation between serum levels of IL17 in the patients with cutaneous warts and age of the patients, number of the warts, duration of the disease.
Also, the present study found that there was no a statstically significant difference between serum levels of IL17 in the patients with cutaneous warts compared with sex, smoking, types of the warts, recurrence, and family history.
Conclusion
This study concluded that there was a statistically significant low serum levels of IL17 in the patients with different cutaneous warts compared with healthy participants that may contribute to development and maintenance of different types of cutaneous warts which depend mainly on the defect of cell mediated immunity.
Recommendations
1. Future studies on large numbers of patients are required to investigate serum levels of IL17 in the patients with different cutaneous warts.
2. Future studies are required to compare the results of serum levels and tissue levels of IL17 in the patients with different cutaneous warts and healthy participants.
3. Future studies are required to investigate the effect of the IL 17 (systemic or intralesional) in treatment of different cutaneous warts.