الفهرس 
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Abstract
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in developed countries, with an increasing prevalence due to an aging population. The pathology underpinning CVD is atherosclerosis, a chronic inflammatory state involving the arterial wall. Progression of atherosclerotic lesions may gradually lead to plaque related complications and clinically manifest as acute vascular syndromes including acute myocardial or cerebral ischemia.
Nanoparticles (NPs) offer a great possibility for biomedical application, not only to deliver pharmaceutics, but also to be used as novel diagnostic and therapeutic approaches. The use of gold nanoparticles in cardiology is promising to develop fundamentally new methods of diagnosis and treatment due to their unique biological properties.
The present study is designed to determine the effect of gold nanoparticles in the treatment of atherosclerosis, also to study its effect on DNA damage of atherosclerotic male rats.
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Abstract
The present study was carried on 80 male albino rats weighing 180-220 g and divided into 8 groups (10 rats for each group). The first one is control group fed with normal laboratory diet (NLD). group II fed with NLD then exposed to 650nm laser light for 5 minutes. group III fed with NLD then injected with 50 μl of 20 nm gold nanoparticles (GNPs) 7 days. group IV fed with normal laboratory diet treated with 50 μl of 20 nm GNPs for 7 days and then exposed to 650nm laser light for 5 minutes after 24 h from the last dose of gold nanoparticle injection. group V fed with high fat diet (HFD) for 3 months. group VI fed with HFD for 3 months then exposed to 650nm laser light for 5 minutes. group VII fed with HFD for 3 months then treated with 50 μl of 20 nm GNPs for 7 days. group VIII fed with HFD for 3 months treated with 50 μl of 20 nm GNPs for 7 days and then exposed to 650nm laser light for 5 minutes after 24 h from the last dose of gold nanoparticle injection.
In this study lipids profile, liver enzymes, fasting blood sugar, plasma insulin, creatinine level and comet assay were determined.
c
Abstract
The results showed that the lipids profile, liver enzymes, blood glucose, insulin and creatinine levels were significantly increased in healthy groups (II, III and IV) as compared to control group and also the levels showed significant decrease in atherosclerotic groups from group VI to group VII then group VIII the lowest decrease in compared with group V (P<0.001, P<0.05). Also the percentage of DNA damage values increased in all groups (P < 0.01) as compared to control group. The current study showed the great effective role of gold nanoparticles and laser especially together in the treatment of atherosclerosis, and GNPs potentiates oxidative stress and provides further proof for previous reports that indicated that GNPs has an oxidant effects.