الفهرس | Only 14 pages are availabe for public view |
Abstract Breast cancer is the most common type of malignancy affects females and its presentation is usually asymptomatic and the mass was discovered accidentally by self-examination of the patients for herself. This study was carried out in an attempt to assess adhesion molecules (ICAM-1 and E-selectin) and some inflammatory parameters (IL-l , ESR and CRP) before and after surgery in different stages of breast cancer. This study was carried out on 59 subjects categorized as: group I (Control group), this group consisted of 20 healthy females with age range from 35- 60 years. group II Groupiia group lib group III Included 19 female patients suffering from breast cancer in the early stage (stage I or II). . The patients of group II before surgery. The patients of group II after surgery. Comprised 20 female patients suffering from breast cancer in the late stage (stage III or IV). group Ilia : The patients of group III before surgery. group Ilib : The patients of group III after surgery. The following parameters were determined for all subjects: - Circulating intercellular adhesion molecule-1 (ciCAM-1). - Soluble E-selectin (sE-selectin). - Interleukin-1 (IL-l ). - C-reactive protein (CRP). - Erythrocytic sedimentation rate (ESR). The results showed that: a ICAM-1 and E-selectin levels were non ignificantly increased in early cases before surgery compared to the control group. • Also early case patients showing significant decrease in E-selectin concentration after surgery when compared to before surgery group (P<0.05). • In late case groups, ICAM-1 and E-selectin, levels before surgery showed highly and very highly significant increase respectively (P<O.Ol & <0.001), compared to the control group. While E-selectin level showed very highly significant decrease (P<O.OOl) after surgery when compared to before surgery one. • E-selectin levels showed a highly significant increase in late case groups compared to early case one (P<O.Ol) before surgery and this increase was significant after surgery (P<0.05). |