الفهرس 
Introduction & Aim of the workOnly 14 pages are availabe for public view
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Abstract
This study was carried out at the anaesthia and ICU department in Minia University Hospital during the period from April 2014 to April 2015 after institutional approval and informed consents obtained from all patients prior to entry in to the study It involved fourty patients ASA physical state I & II, aged from 20-60 years old, undergoing surgeries under general anaesthesia was be selected for this prospective randomized double blinded study in Minia University.
The aim of this study is to investigate the effects of dexmedetomidine premedication on the IOP changes after succinylcholine and endotracheal intubation.
Patients were enrolled in a randomized double blind study into two equal groups.
Group (A): they received Received 0.4 μg/kg IV dexmedetomidine in 10 ml of isotonic solution over 10 minutes.
Group (B): they received 10 ml normal saline IV.
The variables include Heart rate, Mean arterial pressure, Intraocular pressure and O2 saturation were recorded before and after the premedication, after induction, after suxamethonium injection and 2,4,6 min after endotracheal intubation,and evaluation of Extubation and recovery time.
The results of this study found that HR and MAP was significantly low in the dexmedetomidine group compared to control group even after Succinylcholine and intubation.
The IOP was significantly decreased after dexmedetomidine administration however after Succinylcholine and intubation it increased but wasn’t exceeded the baseline value and was significantly lower than in the control group .
The extubation quality,sedation score and recovery time there was no significance difference between the two groups.
We concluded that the dexmedetomidine in the dose of 0.4μg/kg IV premrdication, can effectively blunt the rise in IOP associated with administration of suxamethonium ,laryngoscopy and endotracheal intubation ,It also attenuated the hemodynamic response to laryngoscopy and tracheal intubation without significant side effects.