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Abstract This study included 50 subjects divided into three groups: Group I (Idiopathic Thrombocytopenia Purpura group): Included 25 ITP patient with severe thrombocytopenia. Group II (Chronic Hepatitis C patients group): Included 25 chronic Hepatitis with severe thrombocytopenia. Group III (Control group): Included 10 healthy subjects (as control group). All patients and control were submitted to the following investigations: Laboratory investigations: Complete Blood Count (CBC). Liver Function Tests ( ALT , AST , Albumin and INR ) Renal Function Tests (Blood urea , Serum Creatinine ) HCV and HBV Antibody detection by ELISA Special investigations: Bone Marrow Biopsy and examinations to group 1 and group 2 Immature Platelet Functions % for all patients and control group. Results of different groups were compared with each other and were summarized as follows: There was statically significant difference in ALT, AST, Albumin and INR when group 2 was compared to group 3. This significant difference was noticed only in ALT and AST when group 1 was compared to group 3. There was significant decrease in platelet count in group 1 as compared to group 2 and group 3. There is significant increase in IPF in group 1 compared to group 2 and group 3 In patients with chronic Hepatitis C patients were further subdivided into 2 subgroups: Group Ia: chronic hepatitis C with splenomegaly Group Ib: chronic hepatitis C without splenomegaly And we found that there is insignificant difference in platelet count and IPF between the 2 subgroups. There was a statistically significant negative correlation between platelet count and IPF in group 1 ( p =0.04 ) and group 2 ( p value = 0.001 ). There was a significant negative correlation of platelets count with AST and ALT ( p. value = 0.001 ) And there was a significant positive correlation between platelets count and serum albumin ( p value =0.0001 ) And there was a significant positive correlation of IPF% with AST and ALT (p value = 0.002) and negative correlation with albumin ( p value =0.04) In group 1a there was statistically significant positive correlation of platelets count with Haemoglobin ( p value =0.001) and RBCs count (p value=0.02 ). |