![]() | Only 14 pages are availabe for public view |
Abstract Cancer is the worst disease that hazer people health all over the world. Cancer dangerous lies in its ambiguity, as it is a result of abnormal growth of cells that grow and affect normal cells behind it. It can spread in different sites as it uncontrolled in its move or dispersion. Although tumor cells are no longer dependent on the control mechanisms that govern normal cells, they still require nutrients and oxygen in order to grow. All living tissues are amply supplied with capillary vessels, which bring nutrients and oxygen to every cell. As tumors enlarge, the cells in the center no longer receive nutrients from the normal blood vessels. To provide a blood supply for all the cells in the tumor, it must form new blood vessels to supply the cells in the center with nutrients and oxygen. In a process called angiogenesis, tumor cells make growth factors which induce formation of new capillary blood vessels. The cells of the blood vessels that divide to make new capillary vessels are inactive in normal tissue; however, tumors make angiogenic factors, which activate these blood vessel cells to divide. Without the additional blood supplied by angiogenesis, tumors can grow no larger than about half a millimeter. Breast cancer is the most common cancer of women worldwide. It consider the most common cause of death, incidence rate is high in more developed countries and low in less developed ones. In Egypt, the last two decades it increased and still. Cancer treatment is one of the main challenges that face the scientific concern all over the world. The cancer incidence percentage increases year after year. The most used treatment is chemotherapy. The adverse side effects of chemotherapy affect all body .However, it still not effective enough to treat cancer. Bone is considered the most affected by chemotherapy, it causes osteoporosis and in some cases it may cause bone metastasis. In the present work, we used vitamin D in order to prevent chemo therapy effects on bone health of patients. Vitamin D treatment was used in conjunct with chemotherapy during its six cycles. We also tried to find relations between vitamin D treatment and breast cancer recurrence and its effect on other biochemical blood analysis. In the present study, we discussed whatever calcium, phosphorus, alkaline phosphatase and parathyroid hormone had any association with vitamin D supplementation and their effect on bone health either their levels increased or decreased according to chemotherapy cycle. Our result showed that vitamin D treatment is very useful in maintain bone health and to prevent breast cancer recurrence and decreasing CA15-3 levels in blood (breast cancer tumor marker). Our experimental results showed that: Food supply could be a reason for preventing occurrence of breast cancer in women. Vitamin D increase to maintain a healthy life without many problems in bone or cancerous tumors. Summary 50 Vitamin D increase bone health as it increases calcium absorption that considers the main source of bone formation. Vitamin D treatment affect all studied biochemical blood analysis in a way that improve health and prevent breast cancer recurrence Vitamin D treatment increases bone mineral density and that was a main hypothesis of our study. |