الفهرس 
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Abstract
Sleep-disordered breathing (SDB) is highly prevalent in patients with Connective tissue disorders (CTDs).
The aim of this study was to describe and compare the prevalence, severity, and patterns of SDB and associated nocturnal hypoxia among patients with CTDs patients, and control group.
Thirty patients were recruited from outpatient Immunology and Rheumatology clinic of Internal Medicine Department and outpatient clinic of Rheumatology Department of Menoufia University Hospital.
In this study, there were 1 (3.3%) case of Ankylosing spondylitis, 12 (40.0%) cases of Rheumatoid arthritis, 5 (16.7%) case of Behçet syndrome, and 12 (16.7%) case of Systemic lupus erythematosus. thirty healthy individual enrolled as control group. All participants completed polysomnography (PSG).
In the current work, the prevalence of Sleep apnea in CTDs was 18/30(60%). Sleep apnea was obstructive. Mean AHI was 23.42±26.27/h. Among these OSA patients, 36.7% had severe, 10% had moderate, and 36.7% had mild OSA.
In this study, OSA was diagnosed in 9/12(75%) of RA patients, 5/12(42%) of SLE patients, 4/5(80%) of Behcet’s disease and 0/1(0%) of ankylosing spondylitis.
In the present work, there were highly significant positive correlation between AHI in patients and BMI, Neck circumference, ESS, ESR, CRP, and HCT.
It is of interest that we recorded higher levels of CRP in CTDs patients with OSA. We found that ESR is independent risk factors for sleep related breathing disorders with odds ratio 1.90 and CI (1.01 – 4.55).