الفهرس 
Minor aphthous, major aphthous or herpetiform ulceration observed by physician or patient, which recurred at least 3 times in one 12-month period.Only 14 pages are availabe for public view
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Abstract
( Behcet’s disease is a chronic, relapsing, systemic vasculitis of unknown etiology with the clinical features of mucocutaneous lesions and ocular, vascular, articular, gastrointestinal, urogenital, pulmonary and neurologic involvement.The disease is particularly prevalent in ‘Silk Route’ populations but has a global distribution. Behcet’s disease affects primarily young subjects (Erkan Alpsoy& Akman 2006 ).
Behcets disease (BD) is a chronic, inflammatory multisystemic condition of unknown etiology. It is clinically characterized by recurrent orogenital ulcerations, skin eruptions; ocular manifestations; arthritis; Vasculitis and in some cases neurological and large vessel involvement. An etiology has not been defined, but genetic, environmental, viral, bacterial and immunological factors have been proposed as causative agents. The treatment includes colchicines, thalidomide, steroids and immuno-suppressive agents and it is based on the severity of systemic manifestations, such as central nervous system involvement, arterial aneurysms and thrombosis of the major veins. Mortality is related to major system involvement. In this article the different clinical features (Önder and Gürer 2001)
It is controversial whether the Behest’s Disease should be considered ”a disease” or ”a syndrome”. Since it is a well described entity some people refer as ”a disease”, however, lack of a knowing etiology and a wide clinical range seem enough to call it ”a syndrome” (Kontogiannis and Powell 2000 )
Behcets disease is proposed to be due to an antigen/antibody reaction. The antigen can be external (microbial or other) or self-antigen. Self-antigens include HLA-B, S and interphotoreceptor retinoid binding protein, the oral mucosal antigens, and alpha tropomycin.The antibody reaction manifests as changes common to any inflammatory process.(