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Abstract Diabetic ketoacidosis in children is a serious acute complication of diabetes mellitus and continues to be an important cause of morbidity and mortality. Diabetic ketoacidosis is the result of a critical relative or absolute deficit of insulin, resulting in intracellular starvation of insulin-dependent tissues (muscle, liver, adipose), stimulating the release of counter-regulatory hormones (glucagon, catecholamines, cortisol, and growth hormone). The counter-regulatory hormonal responses may also be the result of stress-induced proinflammatory cytokines. They stimulate lipolysis and proteolysis, hepatic and renal glucose production, and hepatic oxidation of fatty acids to ketone bodies. Diabetic ketoacidosis is biochemically defined as a venous pH<7.3 or serum bicarbonate concentration <15 mmol/L, serum glucose concentration >200 mg/dL (11 mmol/L) together with ketonemia, glucosuria and ketonuria. |