الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 182 |  |  |
| | | from | 182 | | |
Abstract
This study was carried out on 75 mature Albino male rats. They were divided into 5 equal groups each of 15 as follows:-
group (1) Control group: non-treated
group (2 & 3) given Ciprofloxacin IP in doses of 0.9 and 1.8 mg/100 gm b.wt. respictively for 5 successive days.
group (4 & 5) given zeSsrocin orally in doses of 4.5 and 9 mg/100 gm b.wt. respictively for 5 successive days.
Blood and tissue samples :
Five rats from each group were sacrificed at one day, one and two weeks pos drug and administration. Blood samples were collected in centrifuge tubes, they were centrifuged for 15 min. at 3000 rpm. Sera were collected and stored at -20 oC until using for analyses of different biochemical parameters.
Animals were immediately dissected out and parts from their livers (2 gm) were taken and wrapped in aluminum foil and kept in liquid nitrogen until used for gene expression of P53 & P21. The results were summarized as follows:-
Effect on serum LDH activity:
The administration of either ciprofloxacin or azithromycin in their therapeutic and double therapeutic dose levels for 5 days to rats elicited non-significant changes in LDH activity after first day post-drugs administration except with therapeutic dose of ciprofloxacin which revealed a significant elevation in serum LDH activity. Meanwhile, both drugs in their two dose levels afforded a significant increase in the enzyme activity after first and second week post –drugs administration compared with control level.