الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 161 |  |  |
| | | from | 161 | | |
Abstract
In recent years, it has become apparent that stromal components in the tumor microenvironment have profound influence on the growth and metastasis of tumors. Tumor associated stroma provides a rich source of potential biomarkers and prognostic information. The main aim of the current study was to clarify the prognostic significance of two stromal markers (Cav-1 and CD10) in invasive and non invasive breast cancer. The study was conducted on 233 cases of breast carcinomas. A manually constructed breast cancer tissue microarray was immunostained with antibodies against Cav-1 and CD10. The expression of both markers was scored. We assessed the association between their expression and clinicopathological variables as well as patient outcome. We concluded that loss of stromal caveolin-1 is a novel breast cancer biomarker that can predict poor clinical outcome in invasive breast carcinoma. Its prognostic significance appears to be independent of epithelial markers status. In DCIS, its loss in tumor stroma may also predict the recurrence and progression to invasive cancer. Stromal CD10 expression in invasive carcinoma has closely correlated with recurrence and decreased overall survival. Our results suggest that decreased CD10 myoepithelial and increased stromal CD10 expression in DCIS cases may confer higher risk of DCIS recurrence.