الفهرس 
Clomipramine hydrochloride (Supranil):Only 14 pages are availabe for public view
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Abstract
Clomipramine hydrochloride is one of the most used tricyclic antidepressant drug in Egypt. Based on chemical structure, the drug contains two benzene rings. Benzene is considered to be toxic and clastogenic agent and can induce mutagenic effects in mammalian cells. So, the present study was designed to investigate the genotoxic effect of Clomipramine on somatic and germ cells in male mice. Three dose levels 0.195 (Low), 0.26 (Medium), and 0.65 (High) mg/20 g BW were used. These doses equal the doses of acceptable daily intake of Clomipramine hydrochloride for human (75 mg, 100 mg, and 250 mg respectively) / 70 kg BW after modification by using surface area ratios Each dose of Clomipramine was orally administrated for two periods, 5 and 30 days. Seven groups of male mice were used in this work. The first group was utilized as a control. Second and third groups were given the low dose, fourth and fifth group were administrated the medium dose, whereas, the sixth and seventh groups were treated with high dose.