الفهرس | Only 14 pages are availabe for public view |
Abstract INTROIJUCTION AND AIM OF THE WORK In vitro irnmunoassays permit the evaluation of the integrity of numerous facets of the immunological system. For studying the host-tumor interactions in patients suffering from squamous cell carcinoma of the larynx, T-lymphocytes counting can reflect the cell-mediated immune response quantitatively, while the leukocyte migration inhibition assay can qualitatively reflect the sensitization of T-lymphocytes to tumor associated antigens and assess the variations in this sensitization occurring with changing clinical stage and during therapy. The aim of this work is to assess these variations follow~J g different surgical techniques; conservation and radical. It has been noticed that too radical a removal of a tumor and especially the removal of the draining lymph nodes producing an immune reaction against it, may in some instances reduce the defense mechanisms of the body against certain cancers. Radical surgery may thus potentiate the dissemination of neoplastic tissues by a direct effect in reducing the body immunity against cancer. |