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Abstract GERD is a normal physiological phenomenon experienced intermittently by most people, particularly after meals it occurs when the amount of gastric juice that refluxes into the esophagus exceeds the normal limit causing symptoms either with mucosal injury i.e. esophagitis(GERD)or without remarkable oesphageal lesion i.e. non erosive reflux disease (NERD). GERD is one of most complication of obesity and it is highly related to BMI. The precise pathophysiological link between obesity and GERD has not been fully elucidated. Individual studies have variably found reduced lower esophageal sphincter (LES) pressure, increased frequency of transient LES relaxations, increased prevalence of hiatal hernia, an increased prevalence of esophageal motor disorders, and disorders of gastric accommodations in obese subjects. Elevated intragastric pressure in patients with central obesity has also been implicated as a contributing factor. The pathophysiology of GERD in patients who are morbidly obese might differ from that of patients who are not obese So that the correction of reflux in patients who are morbidly obese might be better achieved with a procedure that first controls obesity. Aim of work is to assess the possible role of IL6in GERD patients with and without obesity. IL-6 is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response Studies have focused that visceral fat is metabolically active and produce variety of cytokines including IL-6 and TNF which may affect osephagogastric motor activity. .we evaluated serum IL6 is an inflammatory mediator in individual with GERD. This study was conducted on (90) patients: Group (1): Twenty five patients GERD and obese. Group (2): Twenty five patients GERD and non obese. Group (3): Twenty five patients NERD and obese. Group (4): Fifteen patients NERD and non obese. The result are statically and we observed the following : Severity of GERD is increase by increase of age probably as the result of cumulative acid injury over time to esophagus. GERD was equal in both male and female , no sex prdimonace There is no significant relation between IL6 and central obesity There is no significant relation between IL6 and BMI There is no significant relation between BMI and severity of GERD or finding of upper endoscopy There is no significant relation between waist cicumferance and IL6. There is significant relation between IL6 and upper GIT endoscopy finding IL6 level increase in barret esophagus and low in negative finding IL6 can be used as predictor for severity of upper GIT finding in patient complaining of GERD |