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Abstract Twenty patients with hepatosplenic schistosomiasis were included ; n the present study. They were divided clinically into early (group!), moderate (group II) and advancec (group Ill) according to t~e stage of schistoscnal nepa tospl eni c affection. Five control cases ~;•ere a 1 so includec. Ali cases were submitteo tc full clinical examination, ~ a b c ,... a ~ c r- y i r: v e s ~ i g a t i o n s a r. a I ~ ~,· e r b i c +: s y . 6 i c p s i r: s tare c from the liver were exarrined histcpathclogicaily anc histochemically. I r tre present stwdy, a fa1l ~~ seru~ al~urrin and a r i S E’ C f g : 0 b U ~ i n ·1 € ·~· e ~ S ~ e r E C e ’t E- :: : E C y..· i : !”1 : I” E i) r ;:. ~ ,.- E S S C ; t~E stage cf schistcsomal r.epatcsplenic a~fection. The ir,c,·ease i n SG?~ an c SGO’ ccrrelatec ~<>’tr :ne cegree of ,. E -.· e a 1 E C: E ;. t e r s ’ ... E f i t. r c s ; s c ; ..;:- e c : 1 r· 9 : .:_, ..- : s -, a l l crcers; smal~, rr-edic~’” c;r.c large 1-iltr. nflarr.rratcr) cellular infiltrate i n a l 1 groups . S orr e cases i n group I I and g r 0 up I l I showed lobular hepatitis as e>ider.ced by rr.:Jnonuclear cellular infiltra:e i r tre cells.G•oJp I l l (spleccmegaly with sh•cnken liver~ ’ • |