الفهرس | Only 14 pages are availabe for public view |
Abstract Background: The purpose of present study was to evaluate IL-21 levels in the gingival crevicular fluid of patients with chronic periodontitis before and after nonsurgical periodontal therapy in an attempt to assess its role as a diagnostic and prognostic biomarker of periodontal destruction. Subjects and methods: The present study was conducted on 25 individuals Ten of the individuals were healthy and representing the control group, group (A) and 15 were suffering from chronic periodontitis representing group (B). Gingival crevicular fluid samples were collected from both study groups to detect IL-21 levels. Regarding the assessment of IL-21, ELISA technique was used. Group (B) was subjected to scaling and root planing and then were recalled after 4 months from treatment to resample the gingival crevicular fluid and evaluate the changes in clinical parameters after the nonsurgical periodontal treatment. Then all the detected data was subjected to statistical analysis. Results: the current study showed that, there was a statistically significant positive correlation between IL-21 level and all clinical parameters at baseline and after 4 months from non-surgical periodontal treatment. Conclusion: IL-21 may be considered as one of the important diagnostic and prognostic markers of periodontal destruction. |