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Abstract Environmental exposure to electromagnetic fields (EMFs) has been increased throughout the last century and the worldwide using the mobile phone increases the risk of certain biochemical changes. The present study investigated the effect of mobile phone on brain and DNA. Ninety male of rats were allocated into 3 groups, as a control, continuous and discontinuous exposure to EMF using mobile phone (1800 MHz) for 2 hours daily for 2, 4 and 6 weeks. Brain were allocated from each rat to determine the level of Malondialdehyde (MDA), activity of Superoxide dismutase (SOD), Glutathione S- Transferase (GST) and Glutahione peroxidase (GSHPx), level of Serotonin (5-HT), Dopamine (DA) and Nor-epinephrine (NE) as neurotransmitters were determined in brain. DNA fragmentation was also assessed in the liver of rats. A decrease in the level MDA and SOD activity, increase in GSHPx and GST activity, decreased in serotonin content, and increase in dopamine and nor-epinephrine were detected in brain of rats, increase in the fragmentation of DNA in the liver of rats after exposures to EMF by using mobile phone especially in the discontinuous exposure after 4 and 6 weeks. |