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Abstract INTRODUCTION AND AIM OF THE WORK The orbital glands in different mammals exhibit considerable differences and similarities as regards the structure and function. The orbital glands consisted mainly of : - The Harderian gland. The lacrimal gland. The Harderlan gland is one of the major orbital glands of vertebrates (Walls, 1942). This gland has been considered as a sonrce of lubricant for the eye (Cohn, 1955 and Kennedy, 1970) and the bulk of its secretory product is of a lipid nature in mammals (Carriere, 1985). Fnrthermore, the gland is a known sonrce for porphyrin pigment biosynthesis as it manufactures and stores porphyrin (Lin and Nadakavakaren, 1982). The lacrimal gland is found in animals who live in air, but in fishes for example, there is no lacrimal gland, as the water in which they live act in place of tears (Last, 1968). It is presumed that the lacrimal gland is the sonrce of watery layer ofhuman tears (Gillette, Allansmith, Greiner and Janusz, 1980). They also stated that the main lacrimal gland is the sonrce of stimulated tears, while the accessory lacrimal glands provide the basic watery layer of llllStimulated tears. Whereas, under normal circumstances, the tear fluid forms a thin layer approximately 7 -I 0 ).liil thick that covers the corneal and conjunctival epithelium to wet their surfaces (Tabbara and Okumoto, 1982).The nictitating gland is another orbital gland which is found to be embedded in the substance of the third eye lid in some manrmals as in dogs (Miller, Christensen and Evans, 1964). The present study aims to throw some light on the siructural differences and similarities in the orbital glands of some manrmals (Rat, Rabbit and Human) by histological and histochemical techniques. |