الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Diabetes mellitus is the most common endocrine disease in the world. Type 2 diabetes mellitus, which accounts for 90- 95% of diabetes, is due to interplay between defect in insulin secretion and insulin resistance. Fatty liver has emerged as the most common cause of chronic liver disease worldwide.Type2 Diabetes mellitus is a risk factor for progressive liver disease and mortality in patients with fatty liver. So the diagnosis and evaluation of fatty liver is an important part of management of diabetes. So our study aimed to determine the relationship between soluble CD36 and paraoxanase 1 as indicators of insulin resistance and liver health in type 2 diabetes mellitus. The study was carried out in the Clinical Pathology Department, Faculty of Medicine, Minia University. It was conducted on 75 consecutive patients with type 2 DM who were selected from the attendants of the Diabetic Outpatients Clinics of Minia University Hospital, through the period from October, 2011 to April, 2012. The study also included 10 apparently healthy volunteers who served as a control group. All the study subjects were submitted to the following: Clinical history, clinical examination, abdominal examination, abdominal ultrasonography and laboratory investigations (routine and special). Patients of group I, II and III had significantly higher level of fasting glucose, fasting insulin, HOMA/IR, TC, TG and LDL-c than control group. HDL-c showed decreased levels in group I, II and III when compared with control group. Soluble CD36 and paraoxanase 1 showed significant high levels in patient groups than control group. Also, there were significant increase in sCD36 and paraoxanase 1 between patient subgroups. Also, group II and III showed increased level of both sCD36 and praoxanase 1 than group I. Group III showed increased level of sCD36 and paraoxanase than group II. On the opposite side nitric oxide level showed decreased values in patients groups than control. Nitric oxide was decreased in group II and III than group I. Conclusion were : Plasma sCD36 is a significant predictor for early degree of fatty liver in patients with type 2 DM, Strong correlations between fasting insulin and HOMA/IR with sCD36, paraoxanase 1 and nitric oxide. This may help in estimating insulin resistance in type 2 diabetes, there are many potential risk factors for development of diabetic fatty liver including: duration of DM, obesity and dyslipidemia.