الفهرس 
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Abstract
Periodontal disease is a bacteria-induced chronic inflammatory disease affecting the soft and hard supporting structures encompassing the teeth.Several proinflammatory cytokines and chemokines, responsible for tissue destruction are secreted in GCF, it possess a great potential for serving as diagnostic or prognostic markers of the periodontal health, disease and healing after therapy. The collection of GCF is a relatively simple, noninvasive, and site specific procedure Calprotectin is a 36-kDa protein composed of a dimeric complex of 8- and 14-kDa subunits. Neutrophils are the primary source of calprotectin although other cells, such as activated monocytes and macrophages and specific epithelial cells, are also capable of manufacturing the protein. Calprotectin acts as a calcium- and zinc-binding protein with both antimicrobial and antifungal activities. Furthermore, calprotectin plays a role in immune regulation through its ability to inhibit immunoglobulin production and, of particular interest, its role as a proinflammatory protein for neutrophil recruitment and activation Calprotectin concentrations in the GCF were positively correlated to the severity of periodontitis stratified by probing pocket depth, which is the most widely used diagnostic tool for the clinical assessment of connective tissue and bone destruction in periodontitis. Also, there was decreased concentration of calprotectin after non-surgical periodontal therapy.