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Abstract Objectives: The aim of this study is to compare the anti -inflammatory and the anti-microbial effect of the Matricaria chamomilla Fam. Astraceae and the Trigonella foenum-graecum L. Fam. Leguminosae . and to determine their effect on smear layer when used as root canal irrigants. Material and methods: The seeds of Trigonella foenum-graecum L. and flower heads of Matricaria chamomilla L. were percolated in ethanol (70%) till exhaustion to get different Tfractions. These fractions then were subjected to activity -guided fractionation ofplant extracts. Total extract, Petroleum ether, chloroform, ethyl acetate, and the butanol fractions were subjected to anti-inflammatory activity and the antimicrobial test against Staphylococcus aureus and Enterococcus faecalis. The anti-inflammatory activity was carried out following the method of (Domenjoz 1952). |