الفهرس 
General introduction
AntimicrobialsOnly 14 pages are availabe for public view
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Abstract
Antimicrobials are among the most commonly used of all drugs. The thesis is devoted to the development of new methods for the analysis of some antimicrobial drugs, namely: ribavirin (RBV), fluconazole (FLZ), tinidazole (TNZ), linezolid (LNZ), rifampicin (RIF) and terbinafine hydrochloride (TRH) in pharmaceutical preparations and/or in biological fluids.This thesis comprises six main parts.The first one included a general introduction about antimicrobials and their lassification.astability-indicating liquid chromatographic method for the determination of ribavirin (RBV) in presence of its degradation products.Two analytical methods including; derivative spectrophotometry and micellar liquid chromatography were developed for the analysis of fluconazole (FLZ) and tinidazole (TNZ) in their co-formulated tablet. The micellar HPLC method was extended to the analysis of the drugs in biological fluids.Micellar HPLC method using monolithic column was developed for the simultaneous determination of linezolid (LNZ) and rifampicin (RIF) in their single dosage forms, this in addition to their simultaneous determination in spiked human plasma and the determination of RIF individually in spiked human urine. A micellar liquid chromatographic method with fluorimetric detection was applied for the determination of terbinafine (TRH) in pharmaceutical formulations and spiked human plasma. A spectrofluorimetric method was developed for the determination of terbinafine HCl (TRH) and linezolid (LNZ) in their pharmaceutical formulations and spiked human plasma. The principles of the proposed procedures as well as the experimental parameters were investigated. Also, the validation criteria of the developed methods were intensively studied. All the results were statistically analyzed and compared with those obtained by official or comparison methods.