الفهرس | Only 14 pages are availabe for public view |
Abstract The aim of the present study was to produce and evaluate two attenuated rinderpest vaccines as well as an inactivated one. The results obtained showed that the two attenuated rinderpest vaccines were sterile, potent, safe and immunogenic. The sole difference between them was a virus titre of one logio higher with the Vero-vaccine than with BK-vaccine. Criterria of quality evaluation followed were those given by international organizations. The inactivated rinderpest vaccine was produced using Binary ethylenelamine (0.004 M) as an inactivating agent and the rehydragel (A1OH3) as an adjuvant. The inactivated vaccine was proven to be sterile, potent, safe and immunogenic. It was revealed that the level of serum rinderpest neutralizing antibody titre in vaccinated cattle was found to be approximately sustainalble with the use of attenuated rinderpest vaccines; whereas it was found to be diminishing gradually with the inactivated vaccine through a period of 24 weeks study post vaccination. Protein Profile of both attenuated and inactivated rinderpest virus revealed significant differences between them. |