الفهرس | Only 14 pages are availabe for public view |
Abstract ACS encompasses the diagnosis of UA and MI. UA is an acute condition of myocardial ischemia without sufficient severity and duration to result in myocardial necrosis .patients with UA don’t release biomarkers of myocardial necrosis at detectable levels in to blood, and they don’t typically present with ST elevation on the ECG. In acute MI, the severity and duration of myocardial ischemia is sufficient to result in permanent myocardial injury. Patients may present with or without ST segment elevation on the ECG, so the term ACS describe a spectrum of clinical syndromes that ranges from UA to NSTEMI and STEMI. Some risk factors such as age; cigarette smoking; high blood pressure; elevated levels of LDL cholesterol; low levels of HDL cholesterol; family history of premature CHD; and high fasting plasma glucose levels are epidemiologically strongly associated with CHD, the diagnosis of ACS depends on clinical evaluation, ECG criteria, and laboratory investigations especially biomarkers of cardiac damage which include cardiac treponin, CK, CK‐MB and myoglopin. This study involved screening of the pattern of these risk factors and the differences among age groups from which we found that: Male gender as a risk factor was more prominent in younger age groups. Also, family history of either premature coronary artery disease or sudden cardiac death had the highest prevalence among the youngest age group. Diabetes mellitus and hypertension were more prevalent in middle age groups while increased total cholesterol, LDL, triglycerides and obesity were of higher prevalence among the oldest age groups. Current cigarette smoking was more prevalent in the youngest age groups and decreased in older age groups. Group 1 had fewer risk factors as they represented the lowest incidence of diabetes mellitus. Hypertension, obesity, metabolic syndrome. In addition they had better pattern of lipid profile than the other groups. In contrast they had increased incidence of other risk factors as positive family history of premature CAD, higher incidence of current smoking, low HDL value and being male sex. Females have a higher incidence of DM, HTN and more atherogenic lipid profile pattern than males. |