الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 123 |  |  |
| | | from | 123 | | |
Abstract
The present work was carried out to evaluate the possible anti-morbidity effect of secretory-excretory products (SEP) of Schistosoma haematobium eggs, when given to hamsters prior to infection. Multiple small doses of SEP were injected intra-peritoneally into laboratory bred hamsters (100 μg of purified SEP followed 2 weeks later with 2 booster doses of 50 μg at weekly intervals). Animals were infected with S. haematobium cercariae 1week following last booster immunization dose, and the experimental design included three groups of 10 hamsters each; SEP immunized group, infected immunized group and infected control group. All animals were sacrificed 12 weeks post infection. The results revealed significant reduction in worm load (61.37%), tissue egg loads were also the reduction in tissue egg loads was significant (54.85% and 41.57% for hepatic and intestinal ova, respectively) in addition to decreased percent of immature stages and increase in the percent of the dead ova in Oogram pattern. Pathological examination also revealed significant reduction in number of hepatic granuloma (46.06 %). This study could represent an immunization model as a trial to decrease severe morbidity of schistosomiasis haematobium which may be aggravated by serious sequellae.
Key words
S. haematobium- Anti-morbidity- Hamster- Antigen