الفهرس | Only 14 pages are availabe for public view |
Abstract Anesthesia awareness, also known as unintended intraoperative awareness, is the explicit recall of sensory perceptions during general anesthesia. Although it is rare, its incidence may approach 1% in patients at high risk. (1) It has been reported in children and can lead to anxiety and post-traumatic stress disorder. BIS is a processed EEG that is widely accepted and used to assess neurological function and depth of anesthesia, it is one of the measures used to prevent awareness by measuring level of consciousness intra-operatively. Midazolam is a short-acting drug in the benzodiazepine class that is used for inducing sedation and amnesia before medical procedures (6). Midazolam has a fast recovery time and is the most commonly used benzodiazepine as a premedication for sedation. This study was designed to test the hypotheses that, the use of certain sedative agent as midazolam can affect the BIS values in infants and older children. We enrolled 80 pediatric patients divided into two equal groups each included 40 patients, group A did not receive midazolam as a premedication, group B received midazolam, we compared both groups as regards BIS values ( measured before induction, after induction and every ten minutes), inspiratory volume, expiratory volume, respiratory rate, end tidal CO2 and oxygen saturation. Our study showed that Comparing both patient groups as regards BIS values showed significant difference between both groups in the pre-induction period with lower BIS values in group B that received midazolam as a premedication but after that there were no statistically significant difference. During the first 30 minutes the values of end tidal CO2 is significantly higher in group A than in group B. Otherwise No statistically significant difference between both groups as regards the values of the end tidal CO2. Statistically significant difference between both Summary 61 groups as regards the values of the Respiratory rate during the third and the fourth ten minutes of the operation otherwise no significant difference between both groups. No significant difference between both groups as regards inspiratory tidal volume, expiratory tidal volume and oxygen saturation |