الفهرس | Only 14 pages are availabe for public view |
Abstract Chronic obstructive pulmonary disease (COPD) is defined by progressive, irreversible airflow limitation and an inflammatory response of the lungs, usually to cigarette smoke. However, COPD is a heterogeneous disease in terms of clinical, physiological, and pathological presentation. The aim of the study is to measure the diffusion capacity in the different stages of COPD. The pathological hallmarks of chronic obstructive pulmonary disease (COPD) are inflammation of the small airways (bronchiolitis) and destruction of lung parenchyma (emphysema). The functional consequence of these abnormalities is airflow limitation. As regards the whole sample, there was a statistically significant negative (inverse) correlation between TLCO%, TLCO/VA, PCO2 and HCO3 and there was a statistically significant positive (direct) correlation between TLCO%, TLCO/VA, PO2 and Sat O2 .There was a statistically significant positive (direct) correlation between FVC%, FEV1%, FEF25%, FEF50%, FEF75%, TLCO% and TLCO/VA .There was a statistically significant difference between high resolusion CT findings in mild, moderate and very severe COPD. Key Words: COPD-Diffusion capacity of carbon monoxide-Spirometery- Arterial blood gases- High resolution CT. |