الفهرس 
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Abstract
This study was conducted at haematology oncology clinic children’s hospital and maternity hospital Ain Shams University and included 30 female survivors treated for childhood cancer and completed therapy. Also thirty females of the same age range were included as a control group.
This study aimed at evaluation of gonodal function and effect of cancer therapy in long term female survivors of childhood cancer.
All patients were subjected to:
- Full history taking and clinical examination.
- Determination of serum FSH, LH, AMH, GH.
- Pelvic ultrasound.
- The results of this study revealed.
- No female in our study had received pelvic or abdominal irradiation.
- As regard menarche, this study showed no statistically significant difference between patients and control.
- Patients had higher gonadotrophin and lower AMH level than control group.
- Significant correlation between duration of treatment and effection of gonadal function.
- The adverse effects on gonadal function are more prevalent in older age group.
- Lower mean ovarian volume in patients compared to control group.
- No statistically significant difference between patients and control as regard thyroid function tests.
- Significant higher BMI standard deviation score (SDs) in survivors compared to control.
- Patients treated with multi-drug chemotherapy. The ovarian reserve is compromised as well. Although to a lesser extent, these patients are also at risk for premature menopause.
Conclusion:
Cancer treatment involves the risk of compromised fertility and insufficient sex hormone production with secondary consequences for a cancer survivor’s health. The most significant risk factors are age and type of treatment given. In patients treated with multi-drug chemotherapy, the ovarian reserve is compromised. AMH in the serum is an excellent candidate marker of the ovarian reserve in female after cancer treatment. Parameters such as cycle length and FSH serum levels are not accurate markers of ovarian function. Ovarian volume represent valuable maker for ovarian reserve. Preserving fertility is of a high priority to female cancer survivors. .
Cryopreservation of ovarian tissue is possible way of preserving fertility of patients in the future.