الفهرس | Only 14 pages are availabe for public view |
Abstract Recently, statistics show that psychotic disorders become one of the common medical diseases. The prevalence of psychotic disorders increase the likelihood that such disorders will be present as coexisting problems in patients requiring anesthesia. Psychotropic drugs which are important in the treatment of such psychotic disorders can be classified as antidepressants as MAOIs, TCA for treatment of depression & phenothiazines for schizophrenia & BDZ for anxiety & and lithium for bipolar disorders. Drug interaction between these drugs& anesthetic drugs is very important consideration in anesthesia of psychotic patient as may vary from mild interactions -as increase sleep time and CNS depression when accompanying MAOI or TCA with barbiturates or BDZ given as premedications up to severe potentially fatal interactions as severe sympathetic stimulation with intracranial hemorrhage and acute heart failure when giving MAOI or TCA with sympathomimetics. So anesthetic management should include detailed history about the nature of the damags used to treat the psychotic disorder, their doses, duration of taking these medications, and expected adverse effects. Also, premedication with BDZ, atropine better to be avoided. Smaller doses of barbiturates used in patient treated with TCA and antipsychotic drugs. Succinylcholine could be used as intubating muscle relaxaxnt in patients receiving antipsychotic drugs and TCA. Isoflurne is better to be used as inhalational anesthetic. Electroconvulsive therapy (ECT) is a known anaesthetic challenge, in which using a short acting intravenous drugs is accepted as simple and safe regimen for modified ECT. |