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Abstract Job stress can be defined as a situation where stressors (events or >The aim of this study was to investigate some biochemical changes due to job stress. These include the changes in each of; serum cortisol, immunoglobulin G (IgG), highly sensitive C-reactive protein (CRP), cholesterol (Chol), triglycerides (TG), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) levels among a group of workers exposed to job stress namely junior resident doctors in Ain Shams University Hospitals. The current study included two groups; a case group (48 junior resident doctors) and a control group (24 junior nonresident doctors)]. Results showed that working hours were significantly higher in junior resident doctors in Ain Shams University Hospitals compared to junior nonresident doctors. Serum cortisol, immunoglobulin G (IgG), C-reactive protein (CRP)cholesterol (Chol), triglycerides (TO), and low-densit lipoprotein (LDL) were significantly higher in junior resider doctors in Ain Shams University Hospitals compared to junir nonresident doctors, while high-density lipoprotein (HDL) We significantly lower in junior resident doctors in Ain Shan University Hospitals compared to junior nonresident doctors. Conclusion It could be concluded from this study that increasing tl working hours of junior resident doctors in hospitals lead to kind of pressure which might be harmful to them, and tl pressure might cause increase in the levels of some hormon such as cortisol due to a stimulation of the pituitary gland secrete the hormone stimulating the secretion of cortisol frc the adrenal gland, as well as increase in immunoglobulin and increase in some inflammatory materials such as reactive protein highly sensitive in addition to increase in t level of harmful fats in the blood and an acute shortage good fats and it usually affects the situation of health for the doctors as well as increase their ability to interested patients. |