الفهرس | Only 14 pages are availabe for public view |
Abstract Perinatal asphyxia is a common cause of morbidity and mortality in term newborns. In addition perinatal hypoxic ischemic encephalopathy which still the major cause of long term neurological sequalae in childhood develops in one third of asphyxiated infants (Nagdyman et al., 2001). Numerous studies have suggested that free radicals could have a key role in hypoxic ischemic brain damage (Ogihera et al., 2003). The aim of this study was; first to assess the value of malondialdehyde (lipid peroxidation product) measured in the umbilical cord blood as a marker of foetal asphyxia and as a predictor for hypoxic ischemic encephalopathy, and second was to assess the balance between oxidant and antioxidant generating system in the face of foetal asphyxia. We prospectively studied 50 term newborns divided into 25 patients (13 males, 12 females) had perinatal asphyxia, and 25 ages matched controls (11 males, 14 females). |