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Abstract DM represents the major public health disease affecting different body organs. Al and its compounds comprise about 8% of the Earth’s surface; Al occurs naturally in silicates, cryolite, and bauxite rock. Natural processes account for most of the redistribution of Al in the environment. Acidic precipitation mobilizes Al from natural sources, and direct anthropogenic releases of Al compounds associated with industrial processes occur mainly to air. Certain uses lead to the presence of Al in drinking water and foodstuffs. Al compounds are used as food additives and in the manufacture of abrasives, refractories, ceramics, electrical insulators, catalysts, paper, spark plugs, light bulbs, artificial gems, alloys, glass and heat resistant fibres, pharmaceutical and personal care products, preservatives, fillers, colouring agents, anti-caking agents, emulsifiers and baking powders and soy-based infant formula can contain Al. Diabetes and Al intoxication possess the major health problems especially during pregnancy and development of child. One hundred and sixty-eight fertile male and virgin female rats were used for experimentation. Females were mated in a special cage (1male/3 females) during overnight and gestation was determined in the next morning by the presence of sperm in a native vaginal smear. The pregnant rats were arranged into eight groups; control, Morus alba treated group, experimental diabetic, Diabetic and Morus alba , Al-intoxicated group , Morus alba and Al intoxicated group, Experimental diabetic and Al intoxicated group and Morus alba plus diabetic and Al intoxicated group. Each of the experimental groups was sacrificed at parturition, 7, 9 & 14 days-old. Fast blood glucose was determined in maternal serum. Al levels were estimated in sera & cerebellum of mothers as well as cerebellum of 14 days old pups of both control and experimental groups. CHAPTER VI SUMMARY 243 Cerebellum, spinal cord & retinal of both control and experimental groups of the mentioned aging pups were subjected for light & TEM, DNA fragmentation & comet assay investigations. Phytotherapy is frequently used throughout the world for a range of diabetic presentations and considered to be less toxic and free from side effects than synthetic drugs. Therefore, investigations of such medicines have become particularly important. Morus alba (Mulberry tree) of the family Moraceae has been widely cultivated in countries worldwide from temperate to tropical areas. The findings of the present study are summarized as follows: 1. SDS-PAGE phytochemistry: Qualitative &quantitative analyses of protein compounds exhibited obvious similarities in the expression of bands between water and ethyl alcohol extracts of leaves, non-ripened fruits, ripened fruits and bark of Morus alba L. Comparing lanes revealed a close similarities of protein band patterns of different extractions . 2. Body weight of pups: The body weight of pups maternally subjected to diabetes and/or intoxicated with Al which showed that pups maternally diabetic at 1, 7 and 14 days-old had overgrowth weight (macrosomia) comparing with marked depletion of body weight in pups maternally intoxicated with aluminum. Treatment with Morus alba extract led to a marked amelioration of body weight but was still above the normal levels in diabetic group comparing with pups maternally intoxicated with aluminum. . |