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Abstract Cardiovascular complications are the leading causes of mortality in type 1 DM. The severity of this problem is clearly illustrated by the finding that type 1 DM patients suffer from mortality rates many times higher than of the general population. Diabetes increases the risk of heart failure both in men and women, the main etiological factors contributing to heart failure in diabetes are coronary artery disease, systemic hypertension and diabetic cardiomyopathy, in the same time poor glycemic control may be associated with an increased risk of heart failure among adult patients with diabetes. Diabetic cardiomyopathy is a clinical condition in which ventricular dysfunction occurs independently of coronary artery disease and hypertension. It clinically manifests initially as asymptomatic diastolic dysfunction and then progresses to symptomatic heart failure. This work studied the relation between the degree of glycemic control in type 1 DM (by the assessment of level of HbA1c) and cardiac diastolic function. It included 50 subjects with type 1 DM with age ranged from 11 to 29 years and average diabetic duration of 7 years. Cardiac function was assessed by Echocardiographic, Doppler and Tissue Doppler Imaging studies. The study showed that there is statistically significant difference between diabetic population and control group as regard Doppler A wave, E/A ratio, deceleration time and IVRT. Also there was statistically significant difference between the two groups as regard TDI of septal mitral flow with p value < .001 in septal and lateral (e’) and p value < .0001 in septal and lateral E/e’. There was a direct relationship between level of HbA1c and cardiac diastolic function with sensitivity of 92% and specificity of 75%. The level of HbA1c was directly related to septal and lateral E/e’ TDI of mitral flow and there was indirect relationship between HbA1c level and septal and lateral (e’) TDI of mitral flow. There was no significant correlation between duration of diabetes and Doppler and TDI findings in our study. |