الفهرس 
Introduction and Aim of the workOnly 14 pages are availabe for public view
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Abstract
Results In the present work, we studied the effect of mefloquine on the tegument of juvenile and adult S.mansoni worms by scanning electron microscopy. Mice were infected with S.mansoni cercaria and mefloquine was given at 21 and 49 days post infection .Perfusion was done two, three and seven days post treatment.
Total worm burden study :
The percentage of total worm burden was reduced in juvenile .Two days post treatment, it was reduced by 75.9%, while three days post treatment it was reduced by 81.6% and the percentage of total worm burden reduction in juvenile S. mansoni infection one week post treatment was 95.8%. Statistically, there was significant differences between control(untreated) group and perfused groups two days , three days and seven days post treatment(P< 0.001). There was also statistically significant differences between perfused group two days and perfused group seven days post treatment (P< 0.05) table( 1).
In mature infection the total worm burden was reduced. Two days post treatment the percentage of total worm burden reduction was 44.9%, while three days post treatment it was 58.2% and seven days post treatment it was 72.8% . Statistically, there was significant differences between control group and perfused group 2 days, 3 days and 7 days post treatment, (P< 0.001) ,also there was statistically significant differences between perfused group 2 days and perfused group for 7 days post treatment(P= 0.001) table( 2).
Table (1) shows the effect of a single 400 mg/kg oral dose of mefloquine
administered to mice harboring a 21-day-old S. mansoni infection on the total worm burden . Two days post treatment, the percentage of total worm burden reduction was 75.9%, while three days post treatment it was 81.6% and the percentage of total worm burden reduction in juvenile S. mansoni infection one week post treatment was 95.8%. Statistically, there was significant differences between control(untreated) group and perfused groups 2 days , 3 days and 7 days post treatment, also there was statistically significant differences between perfused group 2 days and perfused group 7 days post treatment
Table (1)
Post hoc&p value %Of total worm burden reduction X`±SD N
Mice=
37 Point of
analysis
Groups
control group &perfused group 2 days post treatment < 0.001 15.2±1.8 20 Control
control group & perfused group 3 days post treatment < 0.001 75.9 3.7±0.8 6 2 days post treatment
control group & perfused group for 7 days post treatment< 0.001 81.6 2.8±1.9 5 3 days post treatment
perfused group for 2 days & 7days post treatment< 0.05 95.8 0.7±0.5 6 7 days post treatment