الفهرس | Only 14 pages are availabe for public view |
Abstract Melasma is a common dermatologic presentation all over the world. Its management is a challenge. Although its precise cause is unknown, multiple factors have been implicated III its aetiopathogenesis of which genetic influences and exposure to ultraviolet radiation are the most important. Different clinical patterns of melasma are recognized; centrofacial, malar and mandibular. Histologically, three subtypes of melasma have been described; epidermal with the pigment predominantly in the basal and suprabasal epidermis, dermal with melanin laden macrophages and mixed type. Despite presence of variable topical bleaching creams and chemical peeling agents and laser apparatus, complete eradication of melasma is very difficult. Dark skin typing of our people, excessive sun exposure. and expensive sunblockers make the treatment of melasma is difficult. The aim of this thesis is to evaluate the efficacy and safety of topical 10% zinc sulfate solution in comparison to Kligman’s formula in the treatment of melasma. Fifteen patients with melasma were included in our study. All ofthem are females. The age ranged from 22 to 45years. The type of melasma was determined using wood’s light. The patients were instructed to apply topical 10% zinc sulfate solution on one side of the face and Kligman’s formula cream on the other side. Both agents were applied twice daily for 2 months. |