الفهرس | Only 14 pages are availabe for public view |
Abstract Psoriasis is an immune-mediated, genetic papulosquamus disease of the skin, mucous membranes, nails and joints. It is characterized by cycles of remission and exacerbation. It is a multifactorial disorder caused by the concerted action of multiple disease genes in a single individual triggered by environmental factors. Psoriasis vulgaris is the most prevalent T-lymphocyte–mediated inflammatory disease in humans, which is characterized by hyperproliferation and poor differentiation of epidermal KCs. It is hypothesized that pathological inflammation results from activation of the type 1 T-cell axis in skin lesions. NB-UVB phototherapy emitting light in the 311 nm to 313 nm spectra has been used successfully for the treatment of psoriasis. UVB alters an immunological function. NB-UVB causes greater depletion of T-cells in psoriatic tissue and establish direct cytotoxic actions of UVB on T-cells infiltrating skin lesions. SPs have an essential role in the first line defense of skin diseases including psoriasis. SP-A plays an important role in host defense. While, SP-B molecules integrated in the phospholipids and important for the ability of surfactant to reduce surface tension. The study was done on 20 psoriatic patients and their age ranged from 20-65 years. They were selected from the outpatient clinic of Dermatology, Venereology and Andrology department, Faculty of Medicine, Menoufyia University. All patients were subjected to complete history taking, clinical and dermatological examinations. They were treated with NB-UVB with duration of treatment ranged from 16-24 weeks with a mean of duration 18.05 weeks. |