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Abstract
Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia resulting from defect in insulin secretion, insulin action or both. The chronic hyperglycemia of diabetes is associated with long term damage, dysfunction and failure of various organs.
T2DM, which was previously referred to as non insulin dependent diabetes mellitus, or adult onset diabetes mellitus, accounts for 90–95% of diabetic patients.
Most recently, RBP4 has been introduced as a novel adipokine that plays a role in regulating glucose metabolism and insulin sensitivity.
High plasma RBP4 levels are associated with insulin resistance states suggesting that RBP4 plays a key role in the pathogenesis of insulin resistance in humans and reflects the magnitude of insulin resistance in subjects with obesity, T2DM and non obese subjects with family history of T2DM.
The current study was carried out at the Medical Biochemistry and Internal Medicine Departments, Faculty of Medicine, Menofia University.
The aim of this work is to study the plasma level of RBP4 in human subjects with T2DM. The current study involved 70 individuals: 20 subjects with IGT, 30 diabetic patients with T2DM and 20 healthy subjects served as controls Full history and clinical examination were made to every subject.
Anthropometric measurements were taken include ; weight, height and waist circumference. Calculation of waist to hip ratio and BMI were done.