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Abstract
High-sensitivity C-reactive protein (hs-CRP) plasmatic levels increase in patients with acute coronary syndromes (ACS). Its measurement at hospital arrival may add diagnostic information to extent of coronary disease. The relationship between age and inflammatory state in ACS patients remain to be identified.253 patients with ACS with age ranged from (32-85 years), 76.7% male gender) who had undergone coronary angiography was included in the study. 76 patients (30%) with UA, 56 (22%) with NSTEMI and 121 with STEMI diagnosis (48%). The value of hs- CRP, lipid profile, cardiac enzymes, risk factors, EF% and angiographic data were analyzed and were compared in different age groups. The study population was classified as group 1 (n=68) with age 45 years, group II (n=110) with age45 - 65 years and group III (n=75) 65 years.Young ACS patients (group I) had more prevalence of male sex, smoking, family history, hypertriglyceridemia and low levels of HDL(P0.01, 0.001) and higher incidence of STEMI (P 0.01) and lower prevalence of UA (P 0.01) compared with group II and III. Diabetes mellitus, hypertension, obesity and female gender were more common in group II & III. Besides, hs -CRP was significantly lower in younger age group (group I) (P0.01, 0.001) and the higher values were observed in older age group (group III) (P0.01 versus group II). As regards angiographic analysis group 1 showed a preponderance of single-vessel disease, lower coronary atherosclerotic score and prevalent LAD involvement compared with older age groups.